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Bodybuilders often take HGH in exogenous form to increase HGH production, increasing muscle mass and fat loss[20,25]. HGH is thought to reduce the risk of developing type 2 diabetes . HGH has been shown to increase testosterone levels and inhibit the formation of prostate cancer cells, even in mice lacking the gene encoding the hormone . In particular, it has been shown by others that oral ingestion of HGH (1 μg/kg BW) prevents the induction or progression of prostate cancer in the mouse model . HGH has also been shown to increase resting serum testosterone and reduce levels of the testosterone receptor. Further, both the testosterone and GH levels increase and decrease in the prostate when HGH is chronically administered . In the current study, orally administered oral HGH with testosterone-releasing hormone, produced an increase in circulating testosterone and decreased levels of the testosterone receptor subtype, DHT, in the prostate. Moreover, oral administration of HGH also inhibited the development of prostate cancer. These results indicate that the administration of oral HGH, even in the high dose levels in the current study, can increase testosterone levels and reduce levels of the body sex steroid DHT to reduce the risk of prostate cancer. In conclusion, the present study demonstrates that oral HGH administration reduced the development of prostate cancer in a male mouse model and increased the level of the body sex steroid, DHT in the prostate. It is suggested that the beneficial effects of HGH-induced prostate cancer prevention may be attributed to the increase in circulating testosterone levels. An increased circulating testosterone may be an explanation for the ability of oral HGH-releasing hormone therapy to reduce the carcinogenesis of the prostate in a male mouse model. HGH-induced prostate cancer prevention may also be a mechanism whereby oral administration of HGH is beneficial in preventing cancer of the pancreas and prostate, thereby resulting in a lower risk of developing cancer. As we already demonstrated in our study , oral treatment with HGH may lead to increased levels of circulating testosterone which may benefit cancer prevention through testosterone and other hormones. Similar articles: